| Title |
HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study
|
|---|---|
| Published in |
Journal of neurology, neurosurgery and psychiatry, August 2014
|
| DOI | 10.1136/jnnp-2014-307932 |
| Pubmed ID | |
| Authors |
Julian Gold, Raph Goldacre, Hubert Maruszak, Gavin Giovannoni, David Yeates, Michael Goldacre |
| Abstract |
Even though multiple sclerosis (MS) and HIV infection are well-documented conditions in clinical medicine, there is only a single case report of a patient with MS and HIV treated with HIV antiretroviral therapies. In this report, the patient's MS symptoms resolved completely after starting combination antiretroviral therapy and remain subsided for more than 12 years. Authors hypothesised that because the pathogenesis of MS has been linked to human endogenous retroviruses, antiretroviral therapy for HIV may be coincidentally treating or preventing progression of MS. This led researchers from Denmark to conduct an epidemiological study on the incidence of MS in a newly diagnosed HIV population (5018 HIV cases compared with 50 149 controls followed for 31 875 and 393 871 person-years, respectively). The incidence rate ratio for an HIV patient acquiring MS was low at 0.3 (95% CI 0.04 to 2.20) but did not reach statistical significance possibly due to the relatively small numbers in both groups. Our study was designed to further investigate the possible association between HIV and MS. |
X Demographics
The data shown below were collected from the profiles of 104 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 19 | 18% |
| United States | 17 | 16% |
| Spain | 8 | 8% |
| Australia | 3 | 3% |
| Germany | 2 | 2% |
| Canada | 2 | 2% |
| Ireland | 2 | 2% |
| Belgium | 2 | 2% |
| Switzerland | 1 | <1% |
| Other | 4 | 4% |
| Unknown | 44 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 71 | 68% |
| Scientists | 17 | 16% |
| Practitioners (doctors, other healthcare professionals) | 14 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Norway | 1 | <1% |
| United Kingdom | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 101 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 19% |
| Student > Ph. D. Student | 17 | 16% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 8 | 8% |
| Other | 8 | 8% |
| Other | 24 | 23% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 42% |
| Agricultural and Biological Sciences | 9 | 8% |
| Neuroscience | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Immunology and Microbiology | 5 | 5% |
| Other | 10 | 9% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 180. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2023.
All research outputs
#226,187
of 25,654,806 outputs
Outputs from Journal of neurology, neurosurgery and psychiatry
#75
of 7,432 outputs
Outputs of similar age
#1,810
of 241,833 outputs
Outputs of similar age from Journal of neurology, neurosurgery and psychiatry
#1
of 298 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,833 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 298 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.